Idursulfase is used to treat a certain inherited
condition (mucopolysaccharidosis type II-Hunter syndrome) that causes a
buildup of a certain substance (glycosaminoglycan-GAG) in the body.
Idursulfase works by breaking down GAGs in the body. This medication may
improve how far you can walk.
Read the Patient Information Leaflet if available from
your pharmacist before you start using idursulfase and each time you get an
infusion. If you have any questions, ask your doctor or
pharmacist.
This medication is given by injection into a vein by a
health care professional. It is given as directed by your doctor, usually
once weekly. The first dose is injected slowly into a vein over 3 hours.
Later doses may be given over a shorter time. The dosage and treatment
schedule are based on your medical condition, weight, and response to
treatment.
Infusion reactions may happen during the infusion of
this drug. Your doctor may prescribe other medications before each
treatment to help prevent these side effects. Tell your doctor right away
if you have any symptoms of infusion reactions such as headache, dizziness,
flushing, fever, nausea, or vomiting. Your doctor may slow down or stop
your treatment for some time.
Use this medication regularly to get the most benefit
from it. To help you remember, mark your calendar with a
reminder.
Tell your doctor if your condition gets
worse.
See also Warning and How to Use sections.
Remember that this medication has been prescribed
because your doctor has judged that the benefit to you is greater than the
risk of side effects. Many people using this medication do not have serious
side effects.
A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a
serious allergic reaction, including:
- rash
- itching/swelling (especially of the face/tongue/throat)
- severe dizziness
- trouble breathing
This is not a complete list of possible side effects. If
you notice other effects not listed above, contact your doctor or
pharmacist.
In the US - Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088 or at
www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about
side effects. You may report side effects to Health Canada at
1-866-234-2345.
See also Warning section.
Before using idursulfase, tell your doctor or pharmacist
if you are allergic to it; or if you have any other allergies. This product
may contain inactive ingredients, which can cause allergic reactions or
other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about
all the products you use (including prescription drugs, nonprescription
drugs, and herbal products).
During pregnancy, this medication should be used only
when clearly needed. Discuss the risks and benefits with your
doctor.
It is unknown if this medication passes into breast
milk. Consult your doctor before breastfeeding.
Drug interactions may change how your medications work
or increase your risk for serious side effects. This document does not
contain all possible drug interactions. Keep a list of all the products you
use (including prescription/nonprescription drugs and herbal products) and
share it with your doctor and pharmacist. Do not start, stop, or change the
dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such
as passing out or trouble breathing, call 911. Otherwise, call a poison
control center right away. US residents can call 1-800-222-1222. Canada
residents can call 1-844-764-7669.
Keep all medical and lab appointments.
It is important to get each dose of this medication as
scheduled. If you miss a dose, ask your doctor or pharmacist right away for
a new dosing schedule.
Not applicable. This medication is given in a hospital
or clinic or doctor's office and will not be stored at
home.
